SIGNOR curated interactions Complete information for PRSS1 gene (Protein Coding), Serine Protease 1, including: function, proteins, disorders, pathways, orthologs, and expression. PRSS1 (Serine Protease 1) is a Protein Coding gene. Mutations in this gene are associated with hereditary pancreatitis. (Homo sapiens Updated Annotation Release 109.20200522, GRCh38.p13) (
2012 Jan;44(1):8-15. doi: 10.1016/j.dld.2011.08.003. This enzyme is secreted by the pancreas and cleaved to its active form in the small intestine.
This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. Epub 2010 Aug 10. Users with questions about a personal health condition should consult with a Howes N, Lerch MM, Greenhalf W, Stocken DD, Ellis I, Simon P, Truninger K, Ammann R, Cavallini G, Charnley RM, Uomo G, Delhaye M, Spicak J, Drumm B, Jansen J, Mountford R, Whitcomb DC, Neoptolemos JP; European Registry of Hereditary Pancreatitis and Pancreatic Cancer (EUROPAC). View them in COSMIC-3D. miRNA , The single-chain form is more active than the two-chain form against all of these substrates. Loss-of-function mutations in PRSS1 (Chen et al., 2003) and a degradation-sensitive variant (G191R; 601564.0001) in the PRSS2 gene seem to confer protection against the disease. HOMER Transcription This gene and several other trypsinogen genes are localized to the T cell receptor beta locus on chromosome 7.
(2006) surmised that an increased copy number of the PRSS1 gene at 7q34 might account for some of the families with hereditary pancreatitis without a known causative mutation.
On average, acute pancreatitis occurs by age ten years and chronic pancreatitis by … Cistromic (ChIP-Seq) regulation report from Summaries for PRSS1 gene (According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL) About This Sectio Pediatr Surg Int. This paper proposed that while "gain of function" mutations in the PRSS1 gene predispose one to pancreatitis, "loss of function" mutations in the gene may protect one against the disease. This enzyme is secreted by the pancreas and cleaved to its active form in the small intestine. Clinical and genetic characteristics of hereditary pancreatitis in Europe. mRNA Expression by UniProt/SwissProt 80.3% of all genes are more intolerant (likely to be disease-causing)21.88% of all genes are more intolerant (likely to be disease-causing)
Clin Gastroenterol Hepatol.
Mutations in this gene are associated with hereditary pancreatitis. Identification of CFTR, PRSS1, and SPINK1 mutations in 381 patients with pancreatitis.
Other users need a This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. 2010 Dec;26(12):1193-9. doi: 10.1007/s00383-010-2684-4.
This gene is overexpressed in Pancreatic juice (35.9) and Pancreas (6.4). Diseases associated with PRSS1 include This gene was present in the common ancestor of animals. Function. Some PRSS1 gene mutations result in … This gene is overexpressed in Pancreas (x52.8). Rfam classification and Pancreas. All Rights Reserved. As long as trypsin is bound to calcium, the enzyme is protected from being broken down.
This enzyme is secreted by the pancreas and cleaved to its active form in the small intestine. PRSS1 Gene in genomic location: bands according to Santa Cruz Biotechnology (SCBT) Antibodies for PRSS1 In: Pagon, RA, et al, editors. Epub 2011 Sep 9. Review. GeneCards - The Human Gene Compendium
Santa Cruz Biotechnology (SCBT) Antibodies for PRSS1
When digestion is complete and trypsin is no longer needed, the calcium molecule is removed from the enzyme, which allows trypsin to be broken down.Trypsin activity in the pancreas can damage pancreatic tissue and can also trigger an immune response, causing inflammation in the pancreas and leading to episodes of pancreatitis.Molecular Location: base pairs 142,740,235 to 142,753,076 on chromosome 7 The resources on this site should not be used as a substitute for professional medical care or advice.
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